Kickoff from U.S. Bank Stadium in Minneapolis is set for 4:30 p.m. ET. The latest Vikings vs. Lions odds have Detroit favored by 7 points, while the over/under for total points scored is 44.5 via DraftKings Sportsbook. Before making any Lions vs. Vikings picks, check out the NFL predictions from the SportsLine Projection Model .

Three divisional battles make up the 2025 NFL Christmas Day slate, making it an ideal opportunity to create an NFL parlay. Cowboys vs.

The NFL regular season is nearly over. Here are the latest odds, point spreads and over/under for every single game for Week 16.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Moneyline: Lions -265, Vikings +215 O/U: 45.5 Spread: Broncos -12.5 Moneyline: Broncos -900, Chiefs +600 O/U: 37.5 SATURDAY, DEC. 27 Spread: Chargers -1.5 Moneyline: Texans -105, Chargers -115 O/U: 39.5 Spread: Packers -2.5 Moneyline: Packers -148, Ravens +124 O/U: 40.5 Moneyline: Bengals -345, Cardinals +275 O/U: 53.5 Spread: Steelers -4.5

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.

The New Orleans Saints are looking to make it four wins in a row when they head to Tennessee to take on the Titans on Sunday afternoon. Meanwhile, the Titans ha

NFL Week 16 betting spreads, lines, point totals for every game on NFL Week 16 schedule, with odds for favorites and underdogs in each NFL matchup.

Week 15 had seismic repercussions for the playoffs and this week's odds. Check out the winners and losers so far.

NFL Week 15 betting spreads, lines, point totals for every game on NFL Week 15 schedule, with odds for favorites and underdogs in each NFL matchup.

The Detroit Lions visit the Minnesota Vikings in a Christmas Day matchup that has lost some luster with both teams lagging well behind last year's pace.