The Indianapolis Colts are at home in Week 16 for a Monday Night matchup with the San Francisco 49ers. So who do the NFL ...

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16 ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...

Colts quarterback Philip Rivers should face less pressure his second week back in the NFL, as his team plays the 49ers on ...

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...

Despite an "admirable" showing by Philip Rivers in Week 15, Mike Florio and Chris Simms believe the 49ers offense will ...

The Philip Rivers story continues in Week 16 when he gets the start for the Indianapolis Colts on Monday Night Football ...

Upsets have some extra juice to them in the final stretch of the season, as they could have a significant impact on the ...

In the aftermath of a valiant effort by Philip Rivers and the Indianapolis Colts in Sunday's 18-16 loss to the Seattle ...

San Francisco 49ers coach Kyle Shanahan shared his admiration for Indianapolis Colts quarterback Philip Rivers making his NFL ...

Expert recap and game analysis of the Seattle Seahawks vs. Indianapolis Colts NFL game from December 14, 2025 on ESPN.