The Indianapolis Colts are at home in Week 16 for a Monday Night matchup with the San Francisco 49ers. So who do the NFL ...

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16 ...

Colts quarterback Philip Rivers should face less pressure his second week back in the NFL, as his team plays the 49ers on ...

There were two big changes made to the Indianapolis Colts' second Week 16 injury report. First, Alec Pierce was listed as ...

The Colts are currently riding a four-game losing streak, which is the fourth-longest active streak in the league. If the ...

Colts defensive tackle DeForest Buckner told reporters Friday he's still uncertain whether he'll play in Monday Night ...

The Indianapolis Colts and San Francisco 49ers face off in "Monday Night Football" this week. Check out how to watch on ESPN now.

The Indianapolis Colts may look to acquire a former Pro Bowler to help solve their precarious quarterback situation in 2026.

The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster ...

Multiple lineman and receivers could miss for Green Bay, plus Micah Parsons on defense. Chicago isn’t healthy at wide receiver, but it hasn’t mattemicar lately with their stellar offensive line play ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...