Mac Jones' revitalized play presents the 49ers a compelling trade chip. ESPN highlights his potential to fetch valuable ...

The Indianapolis Colts and San Francisco 49ers face off in "Monday Night Football" this week. Check out how to watch on ESPN ...

Mike Florio is picking the 49ers to win by a touchdown, while Chris Simms is taking San Francisco by 15. "The Colts have ...

ESPN's FPI simulation projects how the 49ers finish the 2025 season, their playoff seed, and how far San Francisco advances.

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...

San Francisco would have a better chance at the No. 1 seed in the NFC playoffs if Seattle can pull off the victory at home.

Hours before the Los Angeles Rams lost to the Seattle Seahawks in Week 16, ESPN dropped its end-of-season predictions for the ...

An ESPN analyst believes the 49ers can make noise in the playoffs, but one fatal flaw could derail San Francisco's postseason ...

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

San Francisco 49ers quarterback Brock Purdy joins NFL Network's "Inside Training Camp Live" to provide a state of the team's ...

Could A.J. Brown be the answer to the San Francisco 49ers' wide receiver needs in 2026? We look at the trade possibilities.

Broadcast and streaming information for the San Francisco 49ers Week 16 'Monday Night Football' matchup against the Indianapolis Colts at Lucas Oil Stadium.