Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 at Lucas Oil Stadium.

Last weekend's loss against the Seattle Seahawks proved that the Colts can still hang with top teams, no matter who's under center. It's hard to believe that a roster this talented could waste an eight-win start, but it's looking more and more probable.

Get the full 49ers practice and media schedule ahead of the Week 16 matchup vs. the Colts, including press conferences with Kyle Shanahan and Brock Purdy.

In the overall AFC playoff picture, they are one game back of the 9-5 Houston Texans for the final wildcard spot. Using The Athletic's playoff simulator, the Colts' playoff chances now sit at just 8%. Their odds of winning the division are at 1%.

The Indianapolis Colts had been in a strong position to make the playoffs all season, but recent circumstances have changed that outlook. Starter Daniel Jones tore his Achilles last week, while sixth-round rookie Riley Leonard has yet to make a start.

The Colts are trying to keep pace in the playoff race. Here's a look at the latest odds, updated AFC playoff picture and remaining schedule.

The Colts famously began the 2025-26 season firing on all cylinders, climbing out to the AFC’s best 7-1 record through eight weeks. After they’d lose to the middling Pittsburgh Steelers in the week following, however, is when nonbelievers began to ...

Colts are leaning on 44-year-old Philip Rivers to rescue their season, and it starts with Week 15 game against Seahawks

So, looking at the charts, if the Colts go 3 – 0, they have approximately a one in three chance to make the playoffs as the division winner, the 6th seed, or the 7th seed. It would mean that there was only a 2% chance that they were excluded from the tourney.