The 49ers running game has been up and down, but they could have an advantage against a very solid Colts run defense ...

It can be tempting for the San Francisco 49ers to overlook the Indianapolis Colts this week. After starting the season 7-1, ...

The Indianapolis Colts will be front and center when they try to pull off the upset against the San Francisco 49ers.

Christian McCaffrey may be a star running back in the NFL but he can now add, actor to his resume. The 29-year-old spoke to ...

Defensive coordinator Robert Saleh and offensive coordinator Klay Kubiak discussed the team's matchup prep, highlighted key ...

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, 2025.

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

It looks like the Indianapolis Colts are rolling with Philip Rivers again for their Monday night matchup against the San Francisco 49ers in Week 16. That gives us another interesting slate of bets to ...

Colts’ Jonathan Taylor; Ricky Pearsall Jr. doesn’t practice but Kyle Shanahan likes his chances to play Monday.

Yardbarker NFL writers identify the MVP for every NFL team, weighing on-field impact, consistency and importance to overall success.

This article was originally published on www.si.com/nfl/49ers/onsi as One 49ers player is almost guaranteed to get a $500k ...

Kyle Shanahan, Christian McCaffrey and more speak to reporters before San Francisco’s practice on Thursday in Santa ...