49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally ...

The San Francisco 49ers and Indianapolis Colts are set to battle on one of the last editions of Monday Night Football in 2025.

Kyle Shanahan revealed who the 49ers' quarterback would have been in Super Bowl LII: none other than the great Philip Rivers.

The San Francisco 49ers put up a ton of points on Monday night, with a ton of production from their star players, and with Week 16 being the fantasy football playoff semifinals in most leagues, it ...

The Detroit Lions loss to the Pittsburgh Steelers on Sunday secured San Francisco's place in the NFC playoff field with three ...

The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

A cross-conference matchup on 'Monday Night Football' in NFL Week 16 has the Indianapolis Colts hosting the San Francisco 49ers. Indy (8-6) has ...

Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of ...

The San Francisco 49ers entered Monday night having already clinched a playoff berth, but their win in Indy reflected a team ...

The San Francisco 49ers have had a strong showing in 2025, leading to _ of their players getting selected to the 2026 Pro ...

Since 2017, the San Francisco 49ers’ front office has consisted of head coach Kyle Shanahan and general manager John Lynch.