NFL Week 16 picks straight up and against spread
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With three weeks remaining in the 2025 NFL regular season, six teams still have realistic shots at the No. 1 overall pick in the 2026 draft.
An NFL survival pool is one of the most popular contests for fans looking to add extra drama to the season. The concept is simple: each week, players pick one NFL team to win. If that team loses, you’re eliminated.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Florio’s pick: Vikings 28, Giants 13. Simms’s pick: Vikings 27, Giants 17. The Chiefs are in “playing out the string” mode for the first time in a long time. Florio’s pick: Titans 20, Chiefs 17.
The league is built on competitive balance that makes sustained success hard. Plus, Joe Burrow isn’t going anywhere and thoughts on Philip Rivers.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Josh Inglis' NFL TD picks and best bets on NFL TD props for every NFL Week 16 game — plus our best NFL TD parlay!
Our latest 2026 NFL mock draft has a few pieces falling into place, though there are still several major unknowns - including QB Ty Simpson.
USA TODAY Touchdown Wire on MSN
Colts vs. 49ers Week 16 betting odds, moneyline, over/under
The Indianapolis Colts will enter their Monday Night matchup against the San Francisco 49ers as the home underdogs. At 8-6 on the season, the Colts have lost four consecutive games and five of six dating back to before their bye week.