NFL Week 17 early picks against spread
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Lions vs. Vikings prediction, odds, start time: 2025 Christmas Day NFL picks from proven model
Kickoff from U.S. Bank Stadium in Minneapolis is set for 4:30 p.m. ET. The latest Vikings vs. Lions odds have Detroit favored by 7.5 points, while the over/under for total points scored is 43.5 via DraftKings Sportsbook. Before making any Lions vs. Vikings picks, check out the NFL predictions from the SportsLine Projection Model .
The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.