The inimitable adaptability of MALDI-TOF/TOF systems enables tissue imaging of intact proteins, as well as of tryptic peptides brought about by on-tissue digestion. Although intact protein imaging can ...

Using MALDI-TOF, researchers can quickly and accurately determine polymer, protein and nucleic acid masses. They can also analyze and resolve complex assortments of smaller peptides and ...

Lack of genomic sequence data and the relatively high cost of tandem mass spectrometry have hampered proteomic investigations into helminths, such as resolving the mechanism underpinning globally ...

A continuous region of coding sequence can be PCR amplified using a 5′ primer possessing a polymerase binding site and a translation initiation site in-frame with the 5′ end of the test sequence. The ...

Perhaps no tool has been as instrumental to the proteomics revolution as the mass spectrometer. With the ability to deconvolute highly complex mixtures over a wide range of abundance levels, these ...

In order to design and develop new pharmaceutical compounds, the distribution of drugs and their metabolites in tissues must be determined to gain in-depth knowledge of the uptake of a drug into its ...

What is MALDI-TOF? How would you use it? How does it work and what is available? Why would you use it? How would it help solve your problems and what answers could it give? Where would you use it?

The interdisciplinary field of spatial biology continues to connect omics research with the goal of understanding the spatial distribution of biomolecules that influence biological processes and ...

Protein profiling, the quantitative assessment of protein-expression levels, has been at the vanguard of a brave new drug pipeline for the last four or five years. However, while the technologies that ...

What is time-of-flight mass spectrometry? How ToF MS has gained more interest since the commercialization of MALDI. Why a high-speed ADC is key to ToF MS performance. Mixed-signal front end that ...

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