The results uncover a notable parallel between the innate and adaptive immune systems. Whereas DNA deamination targeted to endogenous immunoglobulin loci is used to trigger the diversification of ...

APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have intrinsic dinucleotide ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subjected to the host’s deamination system that includes the cytidine-to-uridine (C-to-U) deamination by apolipoprotein B messenger ...

The APOBEC family of enzymes plays an important role in the human immune system by driving changes in immune cells that aid in defense against viruses. A genetic mechanism is more likely to drive ...